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Global riactice Leader's in Brain Science

4/25 (Wed) 16:00 Regular Seminar
Name : 관리자 | Date : 2018.04.19 15:34 | Views : 12121

Title: Decrypting the secret code of axon regeneration


Speaker: Yongcheol Cho, Ph.D.,
            Department of Biological Sciences, Korea University

 
Time: 16:00, April 25 (Wed), 2018
        

Venue: Room 114, Building E4, DGIST


Abstract : One of the biggest mysteries in biological science is why neurons in the central nervous system (CNS) fail to regenerate injured axons when those in the peripheral nervous system (PNS) can successfully do so. A number of patients live with pain and paralysis after an injury to the nervous system or due to neurodegenerative disorders. This is compounded by their desperation at knowing that their current condition will not improve. Paralysis is tragic for not only the patients but also their families, who love and care for them.

   A simple method that has been utilized in an attempt to answer this question is the comparative analysis of tissue from the two systems to identify the extrinsic neuronal factors responsible for the poor regenerative capacity of the CNS. A number of studies have shown that inhibitory molecules produced in the tissue surrounding areas of damage in the CNS, a phenomenon that is not observed in the PNS, are the primary obstacle. However, based on these findings, research over the past 20 years has proven that blocking or eliminating these inhibitory substances does not improve axon regeneration in the CNS, indicating that the intrinsic neuronal mechanisms that enable PNS neurons to regenerate their axons should be investigated. A number of important characteristics of the neuronal nature of axon regeneration have been uncovered, such as regulatory mechanisms by JNK/c-Jun MAPK, mTOR/PTEN, and JAK/STAT pathways. It has recently become clear, however, that multiple complex responses coordinate the regulation of axon regeneration in PNS neurons after injury, thus systematic and comprehensive analysis is still required to fully understand the mechanisms behind this regeneration. With this in mind, we propose three specific goals that need to be achieved in order to reveal the secret of axon regeneration: 1) mapping the “roads of the regeneration process” on the transcriptomic, post-transcriptomic, translatomic, and proteomic levels; 2) explaining how stress induces phase changes in PNS neurons from a resting state to a re-growing state; and 3) developing novel applications that improve axon regeneration in injured CNS neurons.

 

Person in charge : Sora Lee


Contact: srlee@dgist.ac.kr, 053)785-6102

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