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정보마당

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4/18 (Wed) 16:00 Regular Seminar
이름 : 관리자 | 작성일 : 2018.04.13 16:58 | 조회수 : 560

Title: Conformational Mechanism of GPCR Signaling Analyzed by Hydrogen/Deuterium Exchange Mass Spectrometry


Speaker: Ka Young Chung, Ph.D.,
            School of Pharmacy, Sungkyunkwan University


Time: 16:00, April 18 (Wed), 2018
        

Venue: Room 114, Building E4, DGIST


Abstract : Protein-protein interactions and conformational changes of a signaling protein are major mechanisms of cellular signal transduction. To understand the precise signaling mechanism, studies have investigated the structural mechanism of signaling proteins using various biochemical and/or biophysical techniques such as X-ray crystallography, nuclear magnetic resonance (NMR), electron microscopy, and electron paramagnetic resonance. In addition to these techniques, hydrogen/deuterium exchange mass spectrometry (HDX-MS) has been successfully used for conformational analysis of signaling proteins. HDX-MS measures the rate at which peptide amide hydrogen exchanges with deuterium in the solvent. Exposed or flexible regions have higher exchange rates and buried or ordered regions have lower exchange rates. Therefore, HDX-MS is a useful tool for studying protein-protein interaction interfaces and conformational changes during a signaling protein activation. Although HDX-MS does not provide 3-D structural information, it analyzes dynamic protein conformations that are difficult to be analyzed with other techniques. GPCR signal transduction involves extensive protein-protein interactions and conformational changes of related signaling proteins. In this seminar, I will discuss the conformational mechanisms of GPCR signaling analyzed by HDX-MS.

 


Person in charge : Sora Lee


Contact: srlee@dgist.ac.kr, 053)785-6102

 

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