본문바로가기
메뉴바로가기

Global riactice Leader's in Brain Science

정보마당

  • 주요학과행사
  • 공지사항
  • 세미나공지
  • 갤러리
  • 뉴스
  • 자료실
  • FAQ
  • Q&A

Home > 정보마당 > 세미나공지

세미나공지

4/18 (Wed) 16:00 Regular Seminar
이름 : 관리자 | 작성일 : 2018.04.13 16:58 | 조회수 : 35

Title: Conformational Mechanism of GPCR Signaling Analyzed by Hydrogen/Deuterium Exchange Mass Spectrometry


Speaker: Ka Young Chung, Ph.D.,
            School of Pharmacy, Sungkyunkwan University


Time: 16:00, April 18 (Wed), 2018
        

Venue: Room 114, Building E4, DGIST


Abstract : Protein-protein interactions and conformational changes of a signaling protein are major mechanisms of cellular signal transduction. To understand the precise signaling mechanism, studies have investigated the structural mechanism of signaling proteins using various biochemical and/or biophysical techniques such as X-ray crystallography, nuclear magnetic resonance (NMR), electron microscopy, and electron paramagnetic resonance. In addition to these techniques, hydrogen/deuterium exchange mass spectrometry (HDX-MS) has been successfully used for conformational analysis of signaling proteins. HDX-MS measures the rate at which peptide amide hydrogen exchanges with deuterium in the solvent. Exposed or flexible regions have higher exchange rates and buried or ordered regions have lower exchange rates. Therefore, HDX-MS is a useful tool for studying protein-protein interaction interfaces and conformational changes during a signaling protein activation. Although HDX-MS does not provide 3-D structural information, it analyzes dynamic protein conformations that are difficult to be analyzed with other techniques. GPCR signal transduction involves extensive protein-protein interactions and conformational changes of related signaling proteins. In this seminar, I will discuss the conformational mechanisms of GPCR signaling analyzed by HDX-MS.

 


Person in charge : Sora Lee


Contact: srlee@dgist.ac.kr, 053)785-6102

 

IP : 10.140.1.*** share
QRcode
  • twitter
  • facebook
  • me2day
  • yozm
  • clog
  • delicious
첨부파일
%s1 / %s2
 
List Gallery Webzine RSS FEED

번호 파일 제목 이름 작성일 조회수
jpg 관리자 2018.03.13 828
264 pdf 관리자 2018.04.19 16
263 pdf 관리자 2018.04.19 5
pdf 관리자 2018.04.13 36
261 pdf 관리자 2018.04.06 47
260 pdf 관리자 2018.04.04 19
259 pdf 관리자 2018.03.30 75
258 pdf 관리자 2018.03.30 50
257 pdf 관리자 2018.03.13 177
256 pdf 관리자 2018.03.02 193
255 pdf 관리자 2018.02.21 181
254 blank 관리자 2018.01.22 415
253 pdf 관리자 2018.01.08 414
252 pdf 관리자 2017.01.04 414
251 pdf 관리자 2017.01.04 362
250 blank 관리자 2017.12.29 553
249 pdf 관리자 2017.12.20 458
248 pdf 관리자 2017.12.08 385
247 pdf 관리자 2017.12.08 574
246 pdf 관리자 2017.12.08 383
245 pdf 관리자 2017.12.09 442