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Global riactice Leader's in Brain Science

정보마당

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Home > 정보마당 > 세미나공지

세미나공지

3/21 (Wed) 15:00 Regular Seminar
이름 : 관리자 | 작성일 : 2018.03.13 20:48 | 조회수 : 532

Title: Three-dimensional in vitro modeling of the central nervous system

 

Speaker: Eun-Mi Hur, Ph.D.
            College of Veterinary Medicine, Seoul National University
 

Time: 15:00, March 21 (Wed), 2018
        

Venue: Room 114, Building E4, DGIST

 

Abstract : Advances in 3D tissue engineering have yielded a growing list of organ/tissue-mimics. Brain, which is composed of anatomically distinct elements interconnected by neural networks, represents perhaps the most complex organ to reconstruct. Although several strategies have been developed to model the modular or layered architecture of neuronal somata, limited success has been made towards mimicking the organized or aligned nature of nerve fibers. During development, axons follow precise paths and become directionally aligned, and alterations in such alignment are associated with a broad range of neurological diseases. Despite the importance, little attention has been paid to organizing axon fibres and neural connectivity in culture, especially in 3D. In this talk, I will introduce a simple yet effective method to align fiber tracts in 3D neural constructs, a method which can be applied to model normal and diseased neural circuits. By exploiting the elastomeric property of polydimethylsiloxane and kinetics of collagen fibrillogenesis, the hippocampal CA3–CA1 circuit has been reconstructed in a monolithic gel, in which collagen scaffolds aligned in 3D serve as contact guidance cues to direct axon growth. Moreover, our results suggest that structural alignment is important for achieving functional connectivity between CA3 and CA1 neural populations in vitro.


Person in charge : Sora Lee


Contact: srlee@dgist.ac.kr, 053)785-6102

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