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1/23 (Tue) 10:30 Special Seminar
이름 : 관리자 | 작성일 : 2018.01.22 12:59 | 조회수 : 556

Title: Exploring novel roles of neuronal mitochondria and ER through regulation of Ca2+ homeostasis


Speaker: Seok-Kyu Kwon, Ph.D.
               Columbia University 
 

Time: 10:30, January 23 (Tue), 2018
        

Venue: Room 406, Building E4, DGIST

 

Abstract : Understanding the cellular and molecular mechanisms underlying the establishment of neuronal connectivity and synaptic function has been a major goal in neuroscience over the past three
decades. Despite major progress in the identification of some of these mechanisms at the molecular
level, the contribution of specific organelles such as mitochondria and the endoplasmic reticulum
(ER) in synaptic development and function are still fragmentary. One of the main roadblocks to
progress in this field is the need to develop techniques to probe and interfere with organelle function
with high spatial and temporal accuracy.
The basic unit of neuronal connectivity, the synapse, is the close apposition between the axonal
presynaptic boutons and the postsynaptic dendrite of another neuron. Neurotransmitter release is
critically regulated by cytoplasmic levels Ca2+ at presynaptic boutons, and postsynaptically, the
temporal and spatial dynamics of Ca2+ influx also plays critical roles in signal transduction and
information processing. Therefore, identifying novel mechanisms regulating pre- and/or
postsynaptic Ca2+ dynamics in neurons will provide new insights into a wide range of important
neurophysiological functions ranging from synaptic vesicle release to synaptic plasticity. Recent
studies suggested that intracellular organelles like mitochondria and endoplasmic reticulum (ER)
control Ca2+ dynamics through their Ca2+ uptake and release properties in various non-neuronal
cell types. However, their contribution to synapse development and synapse function in neurons is
poorly understood. Here, I would like to introduce my key findings related to neuronal ER and
mitochondria-mediated Ca2+ regulation including: (1) identification of novel functions for
mitochondria in presynaptic Ca2+ dynamics and neurotransmitter release, (2) the importance of
presynaptic mitochondrial size for Ca2+ regulation and axon development, and (3) new functions
for ER-mitochondria coupling in the regulation of postsynaptic Ca2+ dynamics by identifying novel
molecular mechanisms and applying innovative cellular imaging techniques.

 

Person in charge : Ji Min Han


Contact: jm1671@dgist.ac.kr, 053)785-6104

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