본문바로가기
메뉴바로가기

Global riactice Leader's in Brain Science

정보마당

  • 주요학과행사
  • 공지사항
  • 세미나공지
  • 갤러리
  • 뉴스
  • 자료실
  • FAQ
  • Q&A

Home > 정보마당 > 세미나공지

세미나공지

1/12 (Fri) 14:00 Special Seminar
이름 : 관리자 | 작성일 : 2018.01.08 09:56 | 조회수 : 66

Title: noncoding RNAs in the brain


Speaker: Jinju Han, Ph.D.
            Graduate School of Medical Sciences and Engineering, KAIST
 

Time: 14:00, January 12 (Fri), 2018
        

Venue: Room 114, Building E4, DGIST

 

Abstract : Altered microRNA profiles have been implicated in human brain disorders. However, the functional contribution of individual microRNAs to neuronal development and function is largely unknown. Here we report biological functions for miR-19 in adult neurogenesis. We determined that miR-19 is enriched in neural progenitor cells (NPCs) and downregulated during neuronal development in the adult hippocampus. By manipulating miR-19 in NPCs for gain- and loss-offunction studies, we discovered that miR-19 regulates cell migration by directly targeting Rapgef2. Concordantly, dysregulation of miR-19 in NPCs alters the positioning of newborn neurons in the adult brain. Furthermore, we found abnormal expression of miR-19 in human NPCs generated from schizophrenic patient-derived induced pluripotent stem cells (iPSCs) that have been described as displaying aberrant migration. Our study demonstrates the significance of posttranscriptional gene regulation by miR-19 in preventing the irregular migration of adult- born neurons that may contribute to the etiology of schizophrenia.

 

 

Person in charge : Sora Lee


Contact: srlee@dgist.ac.kr, 053)785-6102


 

IP : 10.140.1.*** share
QRcode
  • twitter
  • facebook
  • me2day
  • yozm
  • clog
  • delicious
첨부파일
%s1 / %s2
 
List Gallery Webzine RSS FEED

번호 파일 제목 이름 작성일 조회수
jpg 관리자 2017.08.29 2,746
253 blank 관리자 2018.01.22 14
pdf 관리자 2018.01.08 67
251 pdf 관리자 2017.01.04 43
250 pdf 관리자 2017.01.04 22
249 blank 관리자 2017.12.29 60
248 pdf 관리자 2017.12.20 83
247 pdf 관리자 2017.12.08 113
246 pdf 관리자 2017.12.08 67
245 pdf 관리자 2017.12.08 72
244 pdf 관리자 2017.12.09 69
243 pdf 관리자 2017.11.24 195
242 pdf 관리자 2017.11.23 157
241 pdf 관리자 2017.11.21 116
240 pdf 관리자 2017.11.09 344
239 pdf 관리자 2017.11.03 204
238 pdf 관리자 2017.10.18 313
237 pdf 관리자 2017.10.18 325
236 pdf 관리자 2017.09.20 374
235 pdf 관리자 2017.09.11 472
234 pdf 관리자 2017.09.11 312