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정보마당

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세미나공지

1/12 (Fri) 14:00 Special Seminar
이름 : 관리자 | 작성일 : 2018.01.08 09:56 | 조회수 : 1128

Title: noncoding RNAs in the brain


Speaker: Jinju Han, Ph.D.
            Graduate School of Medical Sciences and Engineering, KAIST
 

Time: 14:00, January 12 (Fri), 2018
        

Venue: Room 114, Building E4, DGIST

 

Abstract : Altered microRNA profiles have been implicated in human brain disorders. However, the functional contribution of individual microRNAs to neuronal development and function is largely unknown. Here we report biological functions for miR-19 in adult neurogenesis. We determined that miR-19 is enriched in neural progenitor cells (NPCs) and downregulated during neuronal development in the adult hippocampus. By manipulating miR-19 in NPCs for gain- and loss-offunction studies, we discovered that miR-19 regulates cell migration by directly targeting Rapgef2. Concordantly, dysregulation of miR-19 in NPCs alters the positioning of newborn neurons in the adult brain. Furthermore, we found abnormal expression of miR-19 in human NPCs generated from schizophrenic patient-derived induced pluripotent stem cells (iPSCs) that have been described as displaying aberrant migration. Our study demonstrates the significance of posttranscriptional gene regulation by miR-19 in preventing the irregular migration of adult- born neurons that may contribute to the etiology of schizophrenia.

 

 

Person in charge : Sora Lee


Contact: srlee@dgist.ac.kr, 053)785-6102


 

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