본문바로가기
메뉴바로가기

Global riactice Leader's in Brain Science

정보마당

  • 주요학과행사
  • 공지사항
  • 세미나공지
  • 갤러리
  • 뉴스
  • 자료실
  • FAQ
  • Q&A

Home > 정보마당 > 세미나공지

세미나공지

09/22 (Fri) 16:00 Invited Speical Seminar
이름 : 관리자 | 작성일 : 2017.09.20 18:28 | 조회수 : 90

Title: A galanin-receptor regulates context-dependent on-food chemotaxis


Speaker: Myung Kyu Choi, Ph.D.     
            Department of Organismic and Evolutionary Biology, Center for Brain Science, Harvard University

 

Time: 16:00, September 22 (Fri), 2017
        

Venue: Room 114, Building E4, DGIST


Abstract : Food searching behavior often involves decision-making processes that can be regulated by contexts. The well-studied chemosensory neural circuit in C. elegans provides an accessible system to address context-dependent modulation of decision-making. We find that on a big lawn of E. coli OP50, the worm still seeks novel foods, such as a small lawn of P. aeruginosa PA14. This on-food chemotaxis is disrupted by mutations in a G-protein coupled receptor npr-9. npr-9 encodes an ortholog of the human galanin-receptors and is expressed in the interneuron AIB1. Expression of npr-9 in AIB is sufficient to rescue the defects in the on-food chemotaxis. Interestingly, the defect of the npr-9 mutants in chemotaxis is specific to the on-food condition, suggesting a role of npr-9 in modulating chemotaxis by context. To characterize the function of npr-9, we analyzed the behavioral effects of mutating tab-1, which encodes a homolog of the mammalian brain-specific homeobox protein that is expressed in a few neurons, including AIB. We find that tab-1 mutant animals are defective in seeking novel foods, similarly as the npr-9 mutants. The mammalian brain-specific homeobox protein interacts with FOXO transcription factors2. We find that FOXO/DAF-16-dependent insulin signaling regulates npr-9 in modulation of chemotaxis. We are currently investigating the mechanisms through which npr-9 and tab-1 regulate the context-dependent decision-making in food chemotaxis. Because tab-1 is involved in harsh touch, we also address how tab-1 regulates two distinct behaviors, on-food chemotaxis and mechanosensation.

 

Person in charge : Sora, Lee


Contact: srlee@dgist.ac.kr, 053)785-6102

IP : 10.140.1.*** share
QRcode
  • twitter
  • facebook
  • me2day
  • yozm
  • clog
  • delicious
첨부파일
%s1 / %s2
 
List Gallery Webzine RSS FEED

번호 파일 제목 이름 작성일 조회수
jpg 관리자 2017.08.29 459
238 pdf 관리자 2017.10.18 21
237 pdf 관리자 2017.10.18 9
pdf 관리자 2017.09.20 91
235 pdf 관리자 2017.09.11 92
234 pdf 관리자 2017.09.11 65
233 pdf 관리자 2017.08.25 108
232 pdf 관리자 2017.08.25 73
231 pdf 관리자 2017.08.22 102
230 pdf 관리자 2017.08.22 77
229 pdf 관리자 2017.08.21 73
228 blank 관리자 2017.08.16 84
227 pdf 관리자 2017.06.26 373
226 pdf 관리자 2017.06.19 221
225 pdf 관리자 2017.05.26 315
224 pdf 관리자 2017.05.26 175
223 pdf 관리자 2017.05.23 213
222 pdf 관리자 2017.05.18 205
221 pdf 관리자 2017.05.11 358
220 pdf 관리자 2017.04.26 294
219 pdf 관리자 2017.03.28 300