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Global riactice Leader's in Brain Science

7/18 (Thu) 16:00 Special Seminar
Name : 관리자 | Date : 2019.07.10 11:23 | Views : 263

Title: Fiber-based Bio Interfaces for Neural Control and Tissue Regeneration

 

Speaker: Prof. Seongjun Park. (Department of Bio and Brain Engineering, KAIST)(Host : Han Kyoung Choe)

Time: 16:00, July 18 (Thu), 2019
        

Venue: Room 114, Building E4, DGIST


Abstract :Our ability to understand and to treat neurological disorders relies on understanding of the dynamics and function of the nervous system. With the rapid development of the genetic tools for studies of brain function such as optogenetics, there is also a need for reliable devices capable of delivering and receiving a multitude of neuronal signals. For it, I developed the flexible and biocompatible optoelectronic neural interfaces from use of optogenetics and multimaterial fiber fabrication. Moreover, I applied them to brain mapping, spinal cord modulation, and peripheral nerve regeneration.
Despite the rapid development of neural probes, integration of diverse modalities within a single biocompatible platform remains a challenge. Using thermal drawing process, which was conventionally used for fabrication of optical fibers, I produced flexible all-polymer probes with optical, electrical, and microfluidic capabilities all within the 100 μm-diameter. These probes allowed for one-step surgery, including injection of viral vectors carrying genes of light-sensitive ion channels (opsins) into specific locations of the mouse brain, and subsequent optical stimulation and recording of neural activity during free behavior. Moreover, these flexible probes addressed the biocompatibility challenges from the characteristic of stiff metal- or semiconductor-based probes, and enabled the recording of single-unit action potentials in the long term.
In addition to that, I applied optogenetics and fiber drawing technique in tissue engineering to overcome the limited regenerative ability of the peripheral nervous system following traumatic injury. Motivated by the findings that electrical stimulation promotes axonal growth and functional recovery of peripheral nerves, I explored optogenetics as a means to promote neurite growth. By investigating a broad range of optical stimulation parameters using an in vitro platform of dorsal root ganglia (DRGs) expressing blue-light sensitive cation channel channelrhodopsin 2 (ChR2), I have identified that the conditions led to a three-fold enhancement of neurite outgrowth as compared to unstimulated controls. Furthermore, I have applied thermal drawing process to the biocompatible materials for fabricating the hollow nerve guidance channels, which were used to promote the regeneration of DRGs or induced skeletal muscle cells. Scalable topographical features or porous structures of the scaffolds introduced during the thermal drawing process robustly affected the orientation and extent of cells inside of them.

 

Person in charge : BoGyu Jang

 

Contact: jangbk87@dgist.ac.kr, 053)785-6101

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