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Global riactice Leader's in Brain Science

12/12(Wed) 16:00 Regular Seminar
Name : 관리자 | Date : 2018.12.06 16:11 | Views : 469

Title: Autophagy in brain health and disease


Speaker: Seong-Woon Yu, Ph.D., Department of Brain and Cognitive Sciences, DGIST (Host : Jinsoo Seo)


Time: 16:00, December 12 (Wed), 2018
        

Venue: Room 114, Building E4, DGIST


Abstract : Autophagy is a lysosome-dependent catabolic process for the turnover of obsolete or toxic intracellular materials in eukaryotes. Autophagy plays an important role in normal brain development and functions. Here, we present that autophagy, in contrast to its general perception as a protective process, plays a causative role in the death of adult hippocampal neural stem (HCN) cells by chronic psychological stress. “Autophagic cell death” (or type II programmed cell death) is associated with the formation of autophagic vacuoles without hallmarks of apoptosis. HCN cells have normal apoptotic capacity; nevertheless, autophagy mediates stress-induced cell death, thereby causing the cognitive deficits and suppression of adult hippocampal neurogenesis during chronic stress. It is far from clear yet what molecular mechanisms drive autophagy toward cell death, not survival, as well as the sophisticated intersection of apoptotic and autophagic molecular networks. Our study is the genuine in vivo case of autophagic cell death in a mammalian system, and would be an attractive target for therapeutic intervention for psychological stress-induced disorders.
Another line of research in our group is focused on the roles of autophagy in microglia. Microglia share many characteristics with peripheral macrophages. However, we discovered that autophagy in microglia is suppressed upon activation, in contrast to autophagy stimulation in activated macrophages. And suppressed autophagy impairs phagocytic capacity of microglia for amyloid  clearance. Through combined approaches of metabolomics, bioinformatics as well as neurobiological analysis, we found the PI3K-FOXO3 pathway as a potential target to regulate microglia function.
Of recent, there has been burgeoning interest in the physiological roles and relevant mechanisms of autophagy. Our results will provide the foundation for advancing our understanding of the complex roles of autophagy in the brain.


Person in charge : Sora Lee


Contact: srlee@dgist.ac.kr, 053)785-6102

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