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Global riactice Leader's in Brain Science

11/26 (Mon) 16:00 Special Seminar
Name : 관리자 | Date : 2018.11.20 16:30 | Views : 557

Title: Three-dimensional visualization tools for molecular kinetics and architecture in biological systems


Speaker: Taeyun Ku, M.D., Ph.D., Institute for Medical Engineering and Science, MIT (Host : Han Kyoung Choe)


Time: 16:00, November 26 (Mon), 2018
        

Venue: Room 114, Building E4, DGIST


Abstract : In modern biomedicine, imaging is an essential tool for understanding the organization and functions of our bodies and for aiding in disease diagnosis. A variety of imaging technologies, including radiological and microscopic imaging modalities, have been developed to this aim; however, what we are currently allowed to see are still limited in diversity and completeness in the exploration of complex biological systems such as the brain. In this talk, I will introduce novel three-dimensional (3D) visualization tools across in silico, in vivo, and ex vivo platforms that could enrich our vision by offering more intact and comprehensive biological information than conventional methods. First, I will discuss ideas of reformulating functional molecular imaging methods, such as positron emission tomography and dynamic magnetic resonance imaging, using inspiration from 3D virtual tissue. I will show how uncovered knowledge from unbiased computational simulations on fully accessible, realistic virtual tissue can validate, improve, and create functional imaging principles for measuring brain perfusion and metabolism. Second, I will introduce new tissue engineering technologies including MAP and ELAST for large-scale 3D microscopy to visualize biological architecture with subcellular details and molecular identities. MAP enables large-volume super-resolution imaging and reveals nanoscale organizations such as chemical synapses and neural fibers by transforming intact tissue into expandable materials with preserved biomolecules. ELAST overcomes current limitations of tissue processing and imaging capabilities to facilitate large-scale molecular phenotyping of human systems by modulating the mechanical properties of tissue and enhancing probe penetration. I will also briefly discuss potential applications of functional and structural visualization tools in biological studies.


Person in charge : Sora Lee


Contact: srlee@dgist.ac.kr, 053)785-6102

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