Faculty & Research

DIGST Department of Brain Sciences

Core Research Areas

Research field

Neurodegeneration and Metabolism

  • A study on the molecular and cell biological mechanisms of neurodegeneration and programmed apoptosis of nerve cells and neural stem cells in neurological and psychiatric disorders
  • Development of new disease prediction and diagnosis technology that converges BT and IT
  • A system-level approach to neurogenesis, differentiation, and apoptosis to study the basic principles of the central nervous system
  • A study on the metabolic mechanism of the nervous system for the prevention and treatment of obesity, hypertension, diabetes, and various metabolic diseases
  • Single-molecule/single-cell level research for the development of early diagnosis technology for etiological metabolic regulation diseases of neurometabolic diseases such as neurodegenerative diseases
  • Prevention and treatment of neurometabolic diseases by measuring microscopic changes in metabolites through metabolite analysis

Sensory Neuroscience and Circadian Rhythms

  • The purpose of this study is to understand the basic principles of the structure and function of the sensory system including the chemical senses (smell, taste, pheromone) and sight
  • Basic research on molecular and cell biological mechanisms of chemosensory, nociceptive, and pheromone action
  • Applied research such as the discovery of neuroprotective substances, new disease prediction/diagnosis technology, sensory simulation detection technology, and the development of new neurotools through convergence research with robotics and information and communication technology
  • Molecular, cellular, anatomical, and behavioral approaches to control the biological clock of the brain
  • Principles and applications of various circadian rhythms including circadian rhythms and circadian rhythms
  • Functional link between affective disorders and circadian molecular machinery in circadian disorders
  • Real-time imaging at the single-cell level of neuronal populations for understanding circadian and circadian circadian rhythms

Synapse Neuroscience

  • Identify key principles involved in synaptic system regulation such as synapse creation, function, annihilation, and plasticity by applying the latest neuroscience techniques at the molecular, cellular, and system level
  • Identification of synaptic signal transduction mechanism by identifying the functions of lipids, receptors, ion channels and adhesion proteins present in the nerve cell membrane
  • Development of new control technology through discovery of synapses and neural circuits involved in mental diseases, developmental diseases, degenerative brain diseases, and pain signals

Neural Circuits and Behaviors

  • Emotions and Emotion-Related Behaviors in Mice
  • Molecular and brain neural circuit mechanisms of itchiness, impulsive/habitual behaviors and addictions, and social behaviors were studied in an animal model in mice.
  • Self-receptive sensations and sensory imprints in C. elegans - Generation and function of motor neuron circuits

Computational Neuroscience,
Biophysics, and Quantum Biology

  • Protein thermodynamics, folding mechanics and mutagenesis
  • Protein Kinetics and Structural Changes and Biological Functions
  • Protein-protein and protein-DNA interactions
  • Cell Membrane Receptor Proteins and Signaling
  • Protein aggregation and amyloid fiber formation, neurodegenerative diseases
  • Computational neuroscience
  • Complex system big data analysis on brain connectome, neural circuit, and dementia formation
  • Structural Biology and Quantum Biology
  • Deriving simple principles from complexity

High-Level Cognitive Neuroscience

  • Understanding neural correlates involved in high-level cognition in humans
  • Investigating brain-based computation in the human brain
  • Modeling human behaviors

6 Major Research Areas