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2/7 (Thu) 16:00 Special Seminar
Name : 관리자 | Date : 2019.01.24 16:49 | Views : 1110

Title: Cognitive Flexibility is Improved by Serotonergic Inputs into Orbitofrontal Cortex


Speaker: Jung Ho Hyun, Ph.D., Max Planck Florida Institute for Neuroscience (Host : Han Kyoung Choe)


Time: 16:00, February 7 (Thu), 2019
        

Venue: Room 114, Building E4, DGIST


Abstract : Appropriate choice based on expected outcomes determined by previous experience in similar environments is important in everyday life. However, when the outcomes of decisions consistently violate expectations, new learning is necessary to maximize rewards.
Behavioral flexibility, such as reversal learning - the ability to adapt to new rule when an previously rewarded stimulus is no longer rewarded - is dependent on the serotonergic system and impaired by lesions to the orbitofrontal cortex (OFC) in humans and primates (Clarke et al., 2004). Nevertheless, the circuitry and the mechanism controlling serotonergic neurons during reversal learning remains uncharacterized. Here we found serotonin release from dorsal raphe nucleus (DRN) to the OFC promotes reversal learning. Also, we identified and functionally confirmed a long-range connectivity defining the monosynaptic inputs onto OFC projecting serotonergic neurons of DRN based on genetically defined retrograde tracing strategy. We identified that spatiotemporally precise serotonergic action depolarizes the resting membrane potential and directly enhances the excitability of OFC neurons and offers the enhanced spike probability of OFC network as well. In summary, our findings propose a role for serotonergic action on the neural mechanism for cognitive flexibility in a neural circuit within DRN-OFC area during reversal learning.


Person in charge : Sora Lee


Contact: srlee@dgist.ac.kr, 053)785-6102

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