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Global riactice Leader's in Brain Science

R&D

  • Fields of Research
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  • MOU
  • NRC

Home > R&D > Fields of Research

Fields of Research

  • Research area focused on the cellular and molecular mechanisms of neurodegeneration and programmed cell death of neurons and neural stem cells in neurological disorders.
  • Development of novel disease prediction and diagnosis technologies through the convergence research with BT and IT
  • Research on the basic principles of the central nervous system through the systems-level pproaches to the study of the mechanisms governing neurodevelopment, differentiation, and neurodegeneration
  • Research aimed at understanding the metabolic mechanisms of neural systems about obesity, hypertension, diabetes and various other metabolic diseases for prevention and treatment.
  • Focus on the metabolic regulation of the etiology of neurometabolic diseases like eurodegenerative disorders on a single molecule/cell level to develop the technology for early diagnosis of iseases.
  • Observation of minute changes in metabolite levels using Metabolome analysis, stem cell/gene therapy and calcium channels for research applicable to therapeutic intervention for prevention and treatment of neurometabolic diseases.

 

  • Research aimed at understanding the basic principles underlying the structure and functions of the
    sensory system, including chemical senses (olfaction, pheromone, & taste) and vision.
  • The basic research focused on the cellular and molecular mechanisms of chemical senses, pain,
    pheromone action.
  • Translational research such as the discovery of neuroprotective materials and development of novel disease prediction/diagnosis technologies, new biomimetic sensing technologies and sensory system based neuro-tools through convergence studies with other majors including new biology, robotics, and information technology.
  • Regulatory mechanisms of circadian bioclock in the brain through molecular, cellular, anatomical, and behavioral approaches
  • Principles and applications of diverse biological rhythms including circadian rhythms and ultradian rhythms
  • Functional link between molecular clockwork and mood disorder in diseases and disorders with circadian dysfunction
  • Real-time imaging of neuronal population at a single-cell level to understand circadian and ultradian
    biological rhythms

 

  • Understanding of organizing principles underlying synapse formation, function, plasticity at molecular, cellular and systems levels.
  • Investigation of synaptic transmission mechanismsinvolving membrane lipids, receptors, channels and adhesion molecules.
  • Developing new technical platforms for therapeutic interventions against neuropsychiatric, neurodevelopmental, neurodegenerative, and pain disorders.

 

  • Affective and mood-related behaviors in mice
  • Social behaviors, agony-related behaviors (pain and itch) and addiction in mice
  • Proprioception and sensory imprinting in C. elegans

 

  • Deciphering proteomic structures and functions at an atom level through statistical and computational physics and investigation of physicochemical fundamental of life science in Bio-Neuro-Brain system
  • Mechanisms of protein fibrillization and proteomic principle of neurodegenerative diseases
  • Supercomputing of dementia-predicting big-data andcomplex network analysis
  • Supercomputing-based modeling of protein structure in the brain and nervous system
  • Structure analysis of membrane proteins and receptor proteins in the view of signal transduction
    mechanisms through cell membrane

 

  • Neural correlates of high-level cognition such as language, memory, decision making and prediction, more specifically, the brain mechanism involved in the process of cognitive control, hierarchical structure and automaticity.
  • Functional and structural networks related to human high-level cognition through brain imaging technique using magnetic resonance imaging (MRI), with the hope of delineating the brain map related to processes of the high-level cognition.
  • Deficits in the processes of high-level cognition along with frontal lobe dysfunctions in the patients with neurological diseases or brain damages through neuropsychological methods.